Open AccessPrognostic value of serum thymidine kinase, tissue polypeptide antigen and neuron specific enolase in patients with small cell lung cancer
Author(s) -
Ate van der Gaast,
Wim L.J. van Putten,
R. Oosterom,
Miranda Cozijnsen,
Ronald Hoekstra,
Ted A.W. Splinter
Publication year - 1991
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1991.309
Subject(s) - enolase , lactate dehydrogenase , antigen , lung cancer , thymidine kinase , pathology , cell , biology , medicine , cancer research , immunohistochemistry , immunology , enzyme , biochemistry , virus , herpes simplex virus
In a group of seventy patients with small cell lung cancer the prognostic value of serum tumour markers was determined. Thymidine kinase (TK), tissue polypeptide antigen (TPA) and lactate dehydrogenase (LDH) but not neuron specific enolase (NSE) correlated significantly with survival. Since all markers were strongly interrelated with each other and with the extent of disease, the combined determination of TK, TPA and LDH or the combination of disease extent and a marker yielded no more prognostic information than a single measurement of one of these variables.