Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo | Zendy

DE Khoo | Zendy; Beverley Fermor | Zendy; Francis J. Miller | Zendy; CB Wood | Zendy; K. Apostolov | Zendy; W. R. Barker | Zendy; RCN Williamson | Zendy; NA Habib | Zendy

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Manipulation of body fat composition with sterculic acid can inhibit mammary carcinomas in vivo

Author(s) -

DE Khoo,

Beverley Fermor,

Francis J. Miller,

CB Wood,

K. Apostolov,

W. R. Barker,

RCN Williamson,

NA Habib

Publication year - 1991

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1991.20

Subject(s) - stearic acid , oleic acid , in vivo , endocrinology , medicine , mammary gland , chemistry , in vitro , cancer , biochemistry , biology , breast cancer , microbiology and biotechnology , organic chemistry

Sterculic acid, a delta-9-desaturase inhibitor, administered to rats caused a rise in the stearic:oleic acid ratio of total lipids in peripheral red cells, serum and liver (P less than 0.001). As a reduction in the stearic:oleic acid ratio has been described in cancer cells, we investigated the effect of sterculic acid on tumour growth. Female F344 rats were injected subcutaneously with two different doses of sterculic acid for 4 weeks prior to, and 4 weeks following, implantation of a nitrosomethylurea-induced mammary tumour. Tumour growth was inhibited equally by the two doses of sterculic acid (P less than 0.001). A rise in the stearic:oleic acid ratio of tumours was observed in rats treated for only 16 days with sterculic acid. Manipulation of the tissue stearic:oleic acid ratio inhibits transplanted mammary tumour growth in rats.

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