The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study | Zendy

Mauri Kouri | Zendy; Seppo Pyrhönen | Zendy; JukkaPekka Mecklin | Zendy; Heikki Järvinen | Zendy; A. Laasonen | Zendy; Kaarle Franssila | Zendy; S. Nordling | Zendy

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The prognostic value of DNA-ploidy in colorectal carcinoma: a prospective study

Author(s) -

Mauri Kouri,

Seppo Pyrhönen,

JukkaPekka Mecklin,

Heikki Järvinen,

A. Laasonen,

Kaarle Franssila,

S. Nordling

Publication year - 1990

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1990.420

Subject(s) - ploidy , aneuploidy , colorectal cancer , biology , flow cytometry , univariate analysis , pathology , stage (stratigraphy) , carcinoma , medicine , prospective cohort study , cancer , oncology , gastroenterology , multivariate analysis , immunology , chromosome , genetics , gene , paleontology

One hundred and fifty-seven patients with usual colorectal cancer were analysed prospectively for DNA-ploidy, DNA-index and S-phase fraction (SPF) using flow cytometry. An abnormal DNA-stemline was observed in 68% of tumours. The patients have been followed for a median of 36 months. In univariate analysis, tumour stage was the most significant prognostic factor. After excluding patients with stage D disease, DNA-aneuploidy was significantly associated with a shorter survival and a shorter disease free survival. SPF, however, did not correlate with prognosis. In multiple samples from the same tumour there was on average a 29% difference between the highest and the lowest SPF indicating considerable heterogeneity in proliferative activity within the tumours. In diploid tumours the variation was even higher. Patients with proximal tumours as well as female patients had DNA-diploid tumours more often than the others. This may indicate that there are different, so far unknown, aetiological factors leading to different types of ploidy pattern.

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