Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T | Zendy

Jorge S. Burns | Zendy; Louise Lemoine | Zendy; NR Lemoine | Zendy; ED Williams | Zendy; David WynfordThomas | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T

Author(s) -

Jorge S. Burns,

Louise Lemoine,

NR Lemoine,

ED Williams,

David WynfordThomas

Publication year - 1989

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1989.158

Subject(s) - viral vector , transfection , biology , recombinant dna , cell culture , virology , thyroid , virus , vector (molecular biology) , phenotype , antigen , cancer research , microbiology and biotechnology , expression vector , transformation (genetics) , gene , immunology , genetics

A recombinant murine retroviral vector encoding the SV40 virus large T antigen was used to infect stably an immortal line of differentiated rat thyroid epithelial cells, FRTL-5. Expression of SV40 T transformed these cells to anchorage independence and tumorigenicity but did not alter morphology or abolish tissue-specific functions and growth factor requirements. The resulting phenotype provides a model of well-differentiated human thyroid cancer.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research