Second malignancies in children treated for non-Hodgkin's lymphoma and T-cell leukaemia with the UKCCSG regimens | Zendy

L. Ingram | Zendy; MG Mott | Zendy; JR Mann | Zendy; F. Raafat | Zendy; P J Darbyshire | Zendy; PH Morris Jones | Zendy

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Second malignancies in children treated for non-Hodgkin's lymphoma and T-cell leukaemia with the UKCCSG regimens

Author(s) -

L. Ingram,

MG Mott,

JR Mann,

F. Raafat,

P J Darbyshire,

PH Morris Jones

Publication year - 1987

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1987.91

Subject(s) - medicine , lymphoma , malignancy , incidence (geometry) , cancer , lymphoblastic lymphoma , oncology , immunology , t cell , physics , immune system , optics

Eight children treated between 1977 and 1983 with the UK Children's Cancer Study Group's non-Hodgkin lymphoma (NHL) and T-cell protocols have developed second malignancies within 7 years of commencing treatment. Five developed acute non-lymphoblastic leukaemia and a sixth died from infection while pancytopenic with a pre-leukaemic marrow. The other malignancies were cerebral astrocytoma and an undifferentiated low grade sarcoma. These eight children were included among 261 children studied in the first UKCCSG NHL and T-cell trials giving an actuarial incidence of 7.8% second malignancy at 7 years. Six had received adjuvant radiotherapy which may have contributed to the high incidence of second malignancy.

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