Human hybridomas from patients with malignant disease | Zendy

Karol Sikora | Zendy; T. Reid Alderson | Zendy; John Ellis | Zendy; Julie Phillips | Zendy; James E. M. Watson | Zendy

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Human hybridomas from patients with malignant disease

Author(s) -

Karol Sikora,

T. Reid Alderson,

John Ellis,

Julie Phillips,

James E. M. Watson

Publication year - 1983

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1983.16

Subject(s) - malignant disease , multiple myeloma , microbiology and biotechnology , antibody , lymphocyte , cell culture , dna , biology , virology , immunology , cancer , biochemistry , genetics

Lymphocytes from 180 patients with a variety of malignant diseases were collected and fused with a human myeloma-derived line, LON-LICR-HMy2/CAM1. A total of 162 hybridomas was obtained. Only B lymphocyte markers were found on the surface of the fusion products. Flow cytometric analysis revealed a stably increased DNA content in the hybridoma cells. Some hybridoma supernatants were found to contain new Ig chains. Anti-tumour binding activity was found in 12 supernatants.

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