Increased tissue histamine in tumour-bearing mice and rats | Zendy

C. Burtin | Zendy; P. Scheinmann | Zendy; J C Salomon | Zendy; G Lespinats | Zendy; C Frayssinet | Zendy; B. Lebel | Zendy; P. Canu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Increased tissue histamine in tumour-bearing mice and rats

Author(s) -

C. Burtin,

P. Scheinmann,

J C Salomon,

G Lespinats,

C Frayssinet,

B. Lebel,

P. Canu

Publication year - 1981

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1981.99

Subject(s) - histamine , fibrosarcoma , spleen , methylcholanthrene , hindlimb , biology , pathology , stomach , endocrinology , medicine , carcinogen , genetics

Tissue histamine levels were studied in C3H and C57BL/6 mice bearing a methylcholanthrene-induced fibrosarcoma, in Wag rats bearing an aflatoxin B1-induced hepatoma, and in Commentry rats bearing a grafted hepatoma. Histamine levels were significantly higher (1.5 to 3 fold) in the tumour-bearing animals for ventral and dorsal skin, skeletal muscle and stomach fundus. Total histamine content was increased in the spleen. In C3H mice with McC3-1 fibrosarcoma, the excision of the tumour or its partial regression by intratumoral injections of corynebacterium parvum induced a reversion to normal values. The tumour thus appears responsible for the increased histamine levels in tissues distant from the tumour.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research