Interaction of nitroimidazole drugs with DNA in vitro: Structure-activity relationships | Zendy

R.J. Knox | Zendy; R.C. Knight | Zendy; David Edwards | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Interaction of nitroimidazole drugs with DNA in vitro: Structure-activity relationships

Author(s) -

R.J. Knox,

R.C. Knight,

David Edwards

Publication year - 1981

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1981.261

Subject(s) - nitroimidazole , dna , drug , in vitro , dna damage , cytotoxic t cell , chemistry , mechanism of action , bacteria , pharmacology , biology , biochemistry , genetics , organic chemistry

An electrolytic reduction system has been developed to model the cytotoxic action of a range of nitroimidazole drugs against DNA hypoxic cells or anaerobic microorganisms. THe degree of damage induced by these drugs (measured as the release of [14C]-dT from DNA) and their relative rates of reduction have been correlated with their redox potentials. The results show that the correlation of drug-induced damage and electron affinity is related to the amount of drug reduced, and supports the hypothesis that at the molecular level the cytotoxic mechanism of reduced nitroimidazoles is identical in hypoxic mammalian cells, bacteria and protozoa.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research