Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity | Zendy

Oleg Eremin | Zendy; R.R.A. Coombs | Zendy; J. Ashby | Zendy

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Lymphocytes infiltrating human breast cancers lack K-cell activity and show low levels of NK-cell activity

Author(s) -

Oleg Eremin,

R.R.A. Coombs,

J. Ashby

Publication year - 1981

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1981.167

Subject(s) - antibody dependent cell mediated cytotoxicity , cytotoxicity , lymphocyte , immunology , natural killer cell , cell , peripheral blood , biology , cancer research , medicine , pathology , in vitro , biochemistry , genetics

Lymphocytes infiltrating human primary mammary carcinomas lack ADCC and show low levels of natural cytotoxicity. The peripheral blood lymphocytes, however, show a variable but prominent level of cytotoxicity. Lymphocyte preparations from breast tumours, when mixed with autologous blood lymphocytes, significantly suppress their prominent killer- (K- and NK-) cell activities.

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