Isobologram analysis of the combined effects of anti-tumour platinum complexes and ionizing radiation on mammalian cells | Zendy

I. Szumiel | Zendy; A.H.W. Nias | Zendy

Open Access

Isobologram analysis of the combined effects of anti-tumour platinum complexes and ionizing radiation on mammalian cells

Author(s) -

I. Szumiel,

A.H.W. Nias

Publication year - 1980

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1980.229

Subject(s) - chinese hamster ovary cell , ionizing radiation , platinum , in vitro , radiation , chemistry , radiation dose , cancer research , biophysics , toxicology , nuclear medicine , radiochemistry , medicine , irradiation , biochemistry , biology , physics , optics , receptor , nuclear physics , catalysis

Chinese hamster ovary cells have been treated in vitro with the platinum coordination complexes cis-PAD or CHIP and with radiation, either alone or in combination with different doses and time intervals. The isobologram method has been used to make a graphic comparison of these combined-modality data in terms of additivity and enhancement. The data showed enhancement of the radiation effect by these platinum complexes in many combinations, and a truly synergistic effect in one case. This method of analysis points to the limited usefulness of the parameter dose-modifying effect (DMF) since the most synergistic combination did not have the highest DMF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research