An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein | Zendy

Bertrand Delpech | Zendy; A Delpech | Zendy; Nicole Girard | Zendy; Claude Chauzy | Zendy; R Laumonier | Zendy

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An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein

Author(s) -

Bertrand Delpech,

A Delpech,

Nicole Girard,

Claude Chauzy,

R Laumonier

Publication year - 1979

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1979.148

Subject(s) - mesenchyme , antigen , connective tissue , pathology , fibrosarcoma , biology , immunofluorescence , antiserum , nervous tissue , immunoperoxidase , mesenchymal stem cell , antibody , immunology , medicine , monoclonal antibody , neuroscience

Anti-NSA3 antiserum was found to react with many kinds of benign and malignant tumours, as well as foetal skin and intestinal extracts. The corresponding antigens isolated from nervous tissue, benign breast adenoma, and a fibrosarcoma were compared. Immunoprecipitation cannot distinguish between these antigens, and their amino-acid contents were comparable. However, immuno-absorption identified an antigenic determinant that was confined to nervous tissue. Indirect immunofluorescence further confirmed the validity of the concept of a nervous form vs a mesenchymal form of the antigen. Furthermore, immunofluorescence enabled the localization of the antigen found in non-nervous tissue to mesenchyme (mesenchyme-associated antigen: MAA), whether the mesenchymal tissue be normal (foetal organs), tumoral (fibrosarcoma) or reactional (connective-tissue stroma of epithelial tumours).

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