Adenosine deaminase activity in leukaemia | Zendy

John F. Smyth | Zendy; Kenneth R. Harrap | Zendy

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Adenosine deaminase activity in leukaemia

Author(s) -

John F. Smyth,

Kenneth R. Harrap

Publication year - 1975

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1975.95

Subject(s) - chronic myeloid leukaemia , blast crisis , adenosine deaminase , myeloid , medicine , precursor cell , myeloid leukaemia , immunology , adenosine , biology , cell , genetics

Adenosine deaminase (EC 3.5.4.4., ADA) has been measured in the blast cells of 36 patients with acute lymphoblastic, acute myeloid, chronic myeloid and chronic myeloid blast crisis leukaemia. Particularly high levels were found in acute lymphoblastic and chronic myeloid blast crisis patients. The measurement of ADA may be useful diagnostically in the undifferentiated acute leukaemias and in detecting the early onset of blast crisis in chronic myeloid leukaemia. Possible reasons for the elevation of ADA in malignant cells are discussed.

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