Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats | Zendy

Anne G. Jabara | Zendy; Peter Howard Toyne | Zendy; Alison G. Harcourt | Zendy

Open Access

Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats

Author(s) -

Anne G. Jabara,

Peter Howard Toyne,

Alison G. Harcourt

Publication year - 1973

Publication title -

british journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.833

H-Index - 236

eISSN - 1532-1827

pISSN - 0007-0920

DOI - 10.1038/bjc.1973.8

Subject(s) - 7,12 dimethylbenz[a]anthracene , anthracene , medicine , dmba , endocrinology , mammary carcinoma , chemistry , cancer , carcinoma , carcinogenesis , organic chemistry

A reduction in tumour yield was apparent when progesterone administration was begun 25 days before feeding 7,12-dimethylbenz(a)anthracene (DMBA). This effect was most obvious when the duration of hormone administration was brief. Continuation of progesterone for some time after feeding DMBA caused a progressive diminution of the inhibitory effect, and 135 days of continuous hormone treatment entirely abolished the effects of 25 days pretreatment with the hormone.In contrast, when progesterone injections were begun 2 days after feeding DMBA, there was a trend towards enhancement of tumour yield. Continuous hormone administration appeared more effective than shorter treatment regimens.

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