Open AccessThe Effect Both of Time and Dose Applied on Tumour Incidence Rate in Benzopyrene Skin Painting Experiments
Author(s) -
Lee P,
Julie Ann O’Neill
Publication year - 1971
Publication title -
british journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.833
H-Index - 236
eISSN - 1532-1827
pISSN - 0007-0920
DOI - 10.1038/bjc.1971.90
Subject(s) - benzopyrene , incidence (geometry) , medicine , carcinogen , biology , mathematics , benzo(a)pyrene , genetics , geometry
In two separate experiments benzopyrene has been painted regularly on the backs of mice at difference dose levels.It has been shown that the incidence rate of both tumours and infiltrating carcinomas can be taken as proportional to d(2)(t - w)(k) where t is time from first application, w and k are constants independent of dose, and d is the applied dose.