Regional Influences in Cancer

A reinvestigation of the morphology and possible mechanisms of infiltrative-destructive growth by carcinoma into cartilage is presented. The early disintegration of the pre-existing chondroitin-sulphate is emphasized. The active principles are discussed from the morphological and biochemical points of view. A comparison between the reactions of cartilage and the corresponding stroma reaction of the loose connective tissue favours the suggestion that the unknown ester sulphates of the last-mentioned tissue are of another composition than chondroitin-sulphate. REFERENCES. A METHOD of analysing the "pattern distribution" on graded county mnaps whereby the existence, intensity and extent of regional influences could be measured (Appendix 1) has already been described by Cruickshank (1940). The present paper examines the information obtained by the application of the method. These show the geographical distribution of the relative mortality, fully corrected for age and class of district, from cancer of various organs. With two exceptions (Map 14, without County Boroughs; Map 15, Rural Districts only), the "County" includes the County Boroughs. The reference numbers used in the Tables correspond to those in the original publications; the short titles are a guide to classification, but for serious study