Open AccessGenetic Variation in the Natriuretic Peptide System, Circulating Natriuretic Peptide Levels, and Blood Pressure: An Ambulatory Blood Pressure Study
Author(s) -
Jørgen Jeppesen,
Søren Nielsen,
Christian TorpPedersen,
Tine W. Hansen,
Michael Hecht Olsen,
Nikolaj Drimer Berg,
Allan Linneberg,
Sten Madsbad,
Mogens Fenger
Publication year - 2012
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2012.96
Subject(s) - medicine , blood pressure , ambulatory blood pressure , ambulatory , natriuretic peptide , diastole , genotype , endocrinology , population , confidence interval , brain natriuretic peptide , gene , heart failure , genetics , biology , environmental health
In a large collaborative study (n > 50,000), common variants in the natriuretic peptide (NP) genes were found to be associated with circulating NP levels and also with blood pressure (BP) levels based on office BP measurements (OBPMs). It is unknown if determining an individual's BP by 24-h ambulatory BP measurements (ABPMs) will influence the effect of NP gene variations on BP levels.
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