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All renin arises from prorenin. The proportion of renin relative to prorenin could influence overall renin-angiotensin-aldosterone activity. We sought to determine whether prorenin levels were related to extracellular volume, as reflected by the levels of plasma renin activity (PRA), and to aldosterone.

Plasma Levels of Prorenin and Renin in Blacks and Whites: Their Relative Abundance and Associations With Plasma Aldosterone Concentration