Activation of Heme Oxygenase and Suppression of cGMP Are Associated With Impaired Endothelial Function in Obstructive Sleep Apnea With Hypertension | Zendy

Behrouz Jafari | Zendy; Vahid Mohsenin | Zendy

Open Access

Activation of Heme Oxygenase and Suppression of cGMP Are Associated With Impaired Endothelial Function in Obstructive Sleep Apnea With Hypertension

Author(s) -

Behrouz Jafari,

Vahid Mohsenin

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2012.56

Subject(s) - medicine , obstructive sleep apnea , vasodilation , endocrinology , cyclic guanosine monophosphate , nitric oxide , endothelial dysfunction , heme oxygenase , cardiology , heme , biochemistry , chemistry , enzyme

Obstructive sleep apnea (OSA) is a highly prevalent disorder that increases the risk of systemic hypertension and cardiovascular diseases. Heme oxygenase (HO) has been shown to be upregulated in patients with OSA and its overexpression in mice causes hypertension. End products of HO are carbon monoxide (CO) and bilirubin. CO exerts a pleiotropic action on vasoregulation. Despite high prevalence and incident of hypertension in OSA, its pathophysiology is not well-understood, particularly in regard to varying susceptibility of patients to hypertension. We investigated the role of HO in endothelial dysfunction and hypertension in OSA.

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