Docosahexaenoic Acid Monoacylglyceride Decreases Endothelin-1 Induced Ca2+ Sensitivity and Proliferation in Human Pulmonary Arteries | Zendy

Caroline Morin | Zendy; Samuel Fortin | Zendy; Éric Rousseau | Zendy

Open Access

Docosahexaenoic Acid Monoacylglyceride Decreases Endothelin-1 Induced Ca2+ Sensitivity and Proliferation in Human Pulmonary Arteries

Author(s) -

Caroline Morin,

Samuel Fortin,

Éric Rousseau

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2012.45

Subject(s) - vasoconstriction , endothelin 1 , medicine , endocrinology , vascular smooth muscle , docosahexaenoic acid , rho associated protein kinase , hypoxic pulmonary vasoconstriction , pulmonary hypertension , endothelin receptor , myosin light chain phosphatase , phosphorylation , biology , biochemistry , fatty acid , receptor , polyunsaturated fatty acid , smooth muscle

Pulmonary artery vasoconstriction and vascular remodeling contribute to a sustained elevation of pulmonary vascular resistance and pressure in patients with pulmonary arterial hypertension (PH), an often fatal hemodynamic disease. The effect of docosahexaenoic acid monoacylglyceride (MAG-DHA) and the role of the 17 kDa protein kinase C-potentiated inhibitor protein (CPI-17) were determined on vasoconstriction and smooth muscle cell proliferation of human pulmonary arteries (HPA).

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