Flutamide increases aldosterone levels in gonadectomized male but not female wistar rats | Zendy

Peter Hofmann | Zendy; Marten Michaelis | Zendy; Friedrich Götz | Zendy; C. Bartel | Zendy; Tina Kienitz | Zendy; Marcus Quinkler | Zendy

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Flutamide increases aldosterone levels in gonadectomized male but not female wistar rats

Author(s) -

Peter Hofmann,

Marten Michaelis,

Friedrich Götz,

C. Bartel,

Tina Kienitz,

Marcus Quinkler

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2012.21

Subject(s) - flutamide , medicine , aldosterone , endocrinology , prostate cancer , androgen receptor , cancer

Sex-specific differences in blood pressure (BP) suggest an important modulating role of testosterone in the kidney. However, little is known about the interaction between androgens and the mineralocorticoid aldosterone. Our objective was to determine the effects of testosterone in gonadectomized male and female rats on a low-salt diet, and to determine the effect of androgen receptor (AR) blockade by flutamide on BP and on aldosterone levels.

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