Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice | Zendy

Jianming Ying | Zendy; Deborah Stuart | Zendy; Elaine Hillas | Zendy; Barbu Gociman | Zendy; Nirupama Ramkumar | Zendy; Jean-Marc Lalouel | Zendy; Donald E. Kohan | Zendy

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Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice

Author(s) -

Jianming Ying,

Deborah Stuart,

Elaine Hillas,

Barbu Gociman,

Nirupama Ramkumar,

Jean-Marc Lalouel,

Donald E. Kohan

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2012.16

Subject(s) - endocrinology , medicine , blood pressure , kidney , renin–angiotensin system , messenger rna , in situ hybridization , urinary system , biology , gene , biochemistry

The role of proximal tubule (PT) angiotensinogen (AGT) in modulating blood pressure has previously been examined using mice expressing PT human AGT and human renin, or rat AGT. These animals are hypertensive; however, the question remains whether alterations in mouse PT AGT alone affects arterial pressure.

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