The Association of the R563Q Genotype of the ENaC With Phenotypic Variation in Southern Africa | Zendy

Erika Jones | Zendy; E. Owen | Zendy; Brian Rayner | Zendy

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The Association of the R563Q Genotype of the ENaC With Phenotypic Variation in Southern Africa

Author(s) -

Erika Jones,

E. Owen,

Brian Rayner

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2012.125

Subject(s) - medicine , epithelial sodium channel , amiloride , aldosterone , blood pressure , cape , endocrinology , plasma renin activity , negroid , genotype , renin–angiotensin system , sodium , genetics , epidemiology , biology , gene , history , chemistry , organic chemistry , archaeology

The epithelial sodium channel (ENaC) may be a common underlying pathway for the development of primary hypertension. In South Africa, the R563Q variant of the ENaC is associated with low-renin-low-aldosterone hypertension and preeclampsia in black Africans and mixed-ancestry peoples. The purpose of this study was to investigate the prevalence of the R563Q variant in the multiethnic populations of South Africa, its association with hypertension and response to amiloride in patients with resistant hypertension.

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