Prediction of Preeclampsia by Combining Serum Histidine-Rich Glycoprotein and Uterine Artery Doppler | Zendy

Marie Bolin | Zendy; AnnaKarin Wikström | Zendy; Eva WibergItzel | Zendy; AnnaKarin Olsson | Zendy; Maria Ringvall | Zendy; Inger Sundström Poromaa | Zendy; Ove Axelssön | Zendy; B. Thilaganathan | Zendy; Helena Åkerud | Zendy

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Prediction of Preeclampsia by Combining Serum Histidine-Rich Glycoprotein and Uterine Artery Doppler

Author(s) -

Marie Bolin,

AnnaKarin Wikström,

Eva WibergItzel,

AnnaKarin Olsson,

Maria Ringvall,

Inger Sundström Poromaa,

Ove Axelssön,

B. Thilaganathan,

Helena Åkerud

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2012.112

Subject(s) - preeclampsia , medicine , uterine artery , obstetrics , pregnancy , gestational age , gestation , gynecology , genetics , biology

Preeclampsia is associated with both maternal and perinatal morbidity and mortality. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. Significantly lower levels of HRG have been demonstrated as early as in the first trimester in women later developing preeclampsia compared with normal pregnancies. The aim of this study was to investigate whether the combination of HRG and uterine artery Doppler ultrasonography can be used as a predictor of preeclampsia.

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