Inhibitory Effect of the D3 Dopamine Receptor on Insulin Receptor Expression and Function in Vascular Smooth Muscle Cells | Zendy

Hefei Huang | Zendy; Yu Han | Zendy; Xiaoyan Wang | Zendy; Caiyu Chen | Zendy; Changqing Yu | Zendy; Duofen He | Zendy; Hongyong Wang | Zendy; Lin Zhou | Zendy; Laureano D. Asico | Zendy; Pedro A. José | Zendy; Chunyu Zeng | Zendy

Open Access

Inhibitory Effect of the D3 Dopamine Receptor on Insulin Receptor Expression and Function in Vascular Smooth Muscle Cells

Author(s) -

Hefei Huang,

Yu Han,

Xiaoyan Wang,

Caiyu Chen,

Changqing Yu,

Duofen He,

Hongyong Wang,

Lin Zhou,

Laureano D. Asico,

Pedro A. José,

Chunyu Zeng

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.41

Subject(s) - insulin receptor , vascular smooth muscle , medicine , endocrinology , receptor , insulin like growth factor 1 receptor , receptor expression , insulin , insulin receptor substrate , irs2 , dopamine receptor , stimulation , biology , insulin resistance , growth factor , smooth muscle

Vascular smooth muscle cell (VSMC) proliferation is regulated by numerous hormones and humoral factors. Our previous study found that stimulation of D(1)-like dopamine receptors inhibited insulin receptor expression and function in VSMCs. We hypothesize that there is also an interaction between D(3) dopamine and insulin receptors, i.e., stimulation of the D(3) receptor inhibits insulin receptor expression and function.

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