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Aliskiren vs. Angiotensin Receptor Blockers in Hypertension: Meta-Analysis of Randomized Controlled Trials
Author(s) -
D. Gao,
Ning Ning,
Xiaolin Niu,
Jia Wei,
Peipei Sun,
Guang Hao
Publication year - 2011
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2011.3
Subject(s) - medicine , aliskiren , angiotensin receptor blockers , irbesartan , pharmacology , randomized controlled trial , cardiology , renin–angiotensin system , blood pressure
Aliskiren, a newly discovered renin inhibitor, blocks the renin-angiotensin system (RAS) from the top of the enzyme cascade and therefore, might provide comparable or even superior clinical efficacy of blood pressure (BP) control than angiotensin receptor blockers (ARBs). With this meta-analysis, we aimed to compare the efficacy and tolerability of aliskiren and ARBs in the treatment of hypertension in the short-term treatment period.

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