DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase | Zendy

John N. Lorenz | Zendy; Naomi Oshiro | Zendy; Elizabeth L. Loreaux | Zendy; Jerry B. Lingrel | Zendy

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DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase

Author(s) -

John N. Lorenz,

Naomi Oshiro,

Elizabeth L. Loreaux,

Jerry B. Lingrel

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.255

Subject(s) - ouabain , endocrinology , medicine , blood pressure , sodium , chemistry , organic chemistry

We have shown that the ouabain-sensitive α2 Na,K-ATPase is required for adrenocorticotropic hormone (ACTH)-induced hypertension and gestational blood pressure regulation. It is therefore of interest to explore whether this binding site participates in the development of other forms of hypertension, such as deoxycorticosterone acetate (DOCA)-salt using mutant mice with altered sensitivity to ouabain.

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