Association of left ventricular mass with the AGTR1 A1166C polymorphism | Zendy

Yu Jin | Zendy; Tatiana Kuznetsova | Zendy; Lutgarde Thijs | Zendy; Boris Schmitz | Zendy; Yanping Liu | Zendy; Kei Asayama | Zendy; StefanMartin Brand | Zendy; Stéphane Heymans | Zendy; E. Brand | Zendy; R. Fagard | Zendy; Jan A. Staessen | Zendy

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Association of left ventricular mass with the AGTR1 A1166C polymorphism

Author(s) -

Yu Jin,

Tatiana Kuznetsova,

Lutgarde Thijs,

Boris Schmitz,

Yanping Liu,

Kei Asayama,

StefanMartin Brand,

Stéphane Heymans,

E. Brand,

R. Fagard,

Jan A. Staessen

Publication year - 2012

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.244

Subject(s) - medicine , interventricular septum , endocrinology , angiotensin ii , essential hypertension , body mass index , genotype , plasma renin activity , allele , cardiology , renin–angiotensin system , blood pressure , biology , genetics , ventricle , gene

The A1166C polymorphism is located within the microRNA-155 binding site of the human angiotensin II (Ang II) type-1 receptor (AGTR1) gene. The C allele interferes with the base-pairing complementariness between AGTR1 mRNA and microRNA-155 and thereby increases AGTR1 protein expression in vitro. We hypothesized that left ventricular (LV) mass is associated with the AGTR1 A1166C polymorphism.

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