Sleep-Time Blood Pressure as a Therapeutic Target for Cardiovascular Risk Reduction in Type 2 Diabetes

Independent studies have found that elevated sleep-time blood pressure (BP) is a better predictor of cardiovascular risk than the awake or 24-h BP means in patients without as well as with diabetes. However, the impact of the alteration over time of ambulatory BP on cardiovascular risk has never been investigated. We evaluated in a subgroup cohort of MAPEC (Monitorización Ambulatoria para Predicción de Eventos Cardiovasculares, i.e., ambulatory blood pressure monitoring for prediction of cardiovascular events) with diabetes whether reduced cardiovascular risk is more related to the progressive decrease of awake vs. asleep BP.