Plasma Renin Activity (PRA) Levels and Antihypertensive Drug Use in a Large Healthcare System | Zendy

John J. Sim | Zendy; S. K. Bhandari | Zendy; Jiaxiao Shi | Zendy; Kamyar KalantarZadeh | Zendy; Scott Rasgon | Zendy; Jean E. Sealey | Zendy; John H. Laragh | Zendy

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Plasma Renin Activity (PRA) Levels and Antihypertensive Drug Use in a Large Healthcare System

Author(s) -

John J. Sim,

S. K. Bhandari,

Jiaxiao Shi,

Kamyar KalantarZadeh,

Scott Rasgon,

Jean E. Sealey,

John H. Laragh

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.216

Subject(s) - medicine , plasma renin activity , blood pressure , quartile , kidney disease , endocrinology , cardiology , renin–angiotensin system , confidence interval

Although hypertension guidelines have utility in treating uncomplicated hypertension, they often overlook the pathophysiologic basis and heterogeneity of hypertension. This may explain the relatively poor hypertension control rates. A proposed approach is to guide addition and subtraction of medications using ambulatory plasma renin activity (PRA) values. To evaluate the heterogeneity of hypertension and the medication burden associated with it, we investigated medication usage in relation to PRA among hypertensive patients within a large ethnically diverse organization.

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