Effects of Spironolactone on Cerebral Vessel Structure in Rats With Sustained Hypertension | Zendy

Christiné S. Rigsby | Zendy; Adviye Ergul | Zendy; Vera Portik Dobos | Zendy; David M. Pollock | Zendy; Anne M. Dorrance | Zendy

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Effects of Spironolactone on Cerebral Vessel Structure in Rats With Sustained Hypertension

Author(s) -

Christiné S. Rigsby,

Adviye Ergul,

Vera Portik Dobos,

David M. Pollock,

Anne M. Dorrance

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.20

Subject(s) - spironolactone , medicine , endocrinology , lumen (anatomy) , electrical impedance myography , blood pressure , western blot , vasodilation , heart failure , biology , biochemistry , gene

Spironolactone prevents eutrophic middle cerebral artery (MCA) remodeling in young stroke-prone spontaneously hypertensive rats (SHRSP). Clinically, it is more relevant to identify treatments that improve vessel structure after hypertension and remodeling has developed. We hypothesized that spironolactone would increase the MCA lumen diameter and reduce the wall/lumen ratio in SHRSP treated from 12 to 18 weeks of age.

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