eNOS and Caveolin-1 Gene Polymorphisms Interaction and Intima Media Thickness: A Proof of Concept Study in ESRD Patients | Zendy

A. Testa | Zendy; Belinda Spoto | Zendy; Maria Cristina Sanguedolce | Zendy; R. M. Parlongo | Zendy; Anna Pisano | Zendy; Giovanni Tripepi | Zendy; Francesco Benedetto | Zendy; Francesca Mallamaci | Zendy; Carmine Zoccali | Zendy

Open Access

eNOS and Caveolin-1 Gene Polymorphisms Interaction and Intima Media Thickness: A Proof of Concept Study in ESRD Patients

Author(s) -

A. Testa,

Belinda Spoto,

Maria Cristina Sanguedolce,

R. M. Parlongo,

Anna Pisano,

Giovanni Tripepi,

Francesco Benedetto,

Francesca Mallamaci,

Carmine Zoccali

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.178

Subject(s) - medicine , enos , proof of concept , intima media thickness , cardiology , caveolin 1 , nitric oxide , nitric oxide synthase , carotid arteries , computer science , operating system

Caveolae are a prominent microdomain in endothelial cells and appropriate localization in caveolae is fundamental for endothelial nitric oxide synthase (eNOS) activity. Since the Glu298Asp variant in the eNOS gene alters caveolar localization of the corresponding enzyme, we tested the interaction between this variant and the rs4730751 polymorphism of the caveolin-1 (CAV-1) gene as related to arterial remodeling in end-stage renal disease (ESRD) patients.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research