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A phenomenon of endothelial impairment, independent of classical cardiovascular risk factors, has been observed in young people. We identified subjects with persistently reduced, or declining, endothelial function during adolescence and early adulthood, without apparent cardiovascular risk, and investigated the clinical relevance of this finding.

Impaired Endothelial Responses in Apparently Healthy Young People Associated With Subclinical Variation in Blood Pressure and Cardiovascular Phenotype