Hyperinsulinemia Increases Placenta Endothelin-Converting Enzyme-1 Expression in Trophoblasts | Zendy

Mogher Khamaisi | Zendy; Galina Skarzinski | Zendy; J. Mekler | Zendy; Farid Zreik | Zendy; Rawan Damouni | Zendy; I. Ariel | Zendy; Michael Bursztyn | Zendy

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Hyperinsulinemia Increases Placenta Endothelin-Converting Enzyme-1 Expression in Trophoblasts

Author(s) -

Mogher Khamaisi,

Galina Skarzinski,

J. Mekler,

Farid Zreik,

Rawan Damouni,

I. Ariel,

Michael Bursztyn

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.164

Subject(s) - endocrinology , medicine , placenta , hyperinsulinemia , endothelin 1 , endothelin receptor , hyperinsulinism , fetus , kidney , intrauterine growth restriction , pregnancy , insulin , biology , receptor , insulin resistance , genetics

Exogenous hyperisulinemia causes pregnancy, induced hypertension and intrauterine growth restriction (IUGR) in pregnant rats. Hyperinsulinemia may increase production of endothelin-1 (ET-1), produced by sequential proteolysis of the big endothelin by the endothelin-converting enzyme (ECE)-1, the expression of which is examined here in the placenta, kidney, heart, and liver.

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