Effect of Angiotensin AT1 Receptor Blockade on Sympathetic Responses to Handgrip in Healthy Men | Zendy

Cheri L. McGowan | Zendy; Catherine F. Notarius | Zendy; Andrea C. McReynolds | Zendy; Beverley L. Morris | Zendy; Derek S. Kimmerly | Zendy; Peter Picton | Zendy; John S. Floras | Zendy

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Effect of Angiotensin AT1 Receptor Blockade on Sympathetic Responses to Handgrip in Healthy Men

Author(s) -

Cheri L. McGowan,

Catherine F. Notarius,

Andrea C. McReynolds,

Beverley L. Morris,

Derek S. Kimmerly,

Peter Picton,

John S. Floras

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.14

Subject(s) - medicine , losartan , isometric exercise , plasma renin activity , angiotensin ii , blood pressure , microneurography , heart rate , endocrinology , placebo , crossover study , reflex , renin–angiotensin system , cardiology , baroreflex , alternative medicine , pathology

To determine whether angiotensin II (ANG II) contributes to the reflex skeletal muscle sympathoexcitation elicited by isometric and isotonic exercise, we tested the hypothesis that angiotensin AT(1) receptor blockade (ARB) would attenuate reflex sympathoneural responses to handgrip (HG) and to post-handgrip ischemia (PHGI).

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