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Inflammation and oxidative stress have been identified as integral parts in the pathogenesis of hypertension. Cyclo-oxygenase-2 which could elicit inflammation and free radicals generation appears to be a key enzyme in hypertension. Cyclo-oxygenase-2 expression and oxidative stress in cardiovascular tissues are increased in the angiotensin II model.

Cyclo-Oxygenase-2 Knockout Genotype in Mice Is Associated With Blunted Angiotensin II-Induced Oxidative Stress and Hypertension