Cyclo-Oxygenase-2 Knockout Genotype in Mice Is Associated With Blunted Angiotensin II-Induced Oxidative Stress and Hypertension | Zendy

Rongqian Wu | Zendy; Sonia Duchemin | Zendy; MarcAndré Laplante | Zendy; Jacques de Champlain | Zendy; Hélène Girouard | Zendy

Open Access

Cyclo-Oxygenase-2 Knockout Genotype in Mice Is Associated With Blunted Angiotensin II-Induced Oxidative Stress and Hypertension

Author(s) -

Rongqian Wu,

Sonia Duchemin,

MarcAndré Laplante,

Jacques de Champlain,

Hélène Girouard

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.137

Subject(s) - angiotensin ii , superoxide , oxygenase , oxidative stress , heme oxygenase , medicine , endocrinology , renin–angiotensin system , superoxide dismutase , chemistry , biochemistry , enzyme , receptor , blood pressure , heme

Inflammation and oxidative stress have been identified as integral parts in the pathogenesis of hypertension. Cyclo-oxygenase-2 which could elicit inflammation and free radicals generation appears to be a key enzyme in hypertension. Cyclo-oxygenase-2 expression and oxidative stress in cardiovascular tissues are increased in the angiotensin II model.

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