MicroRNA-130a Mediates Proliferation of Vascular Smooth Muscle Cells in Hypertension | Zendy

Wenwen Wu | Zendy; Chengping Hu | Zendy; X.-P. Chen | Zendy; Weifang Zhang | Zendy; X.-W. Li | Zendy; Xiaofang Xiong | Zendy; Y.-J. Li | Zendy

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MicroRNA-130a Mediates Proliferation of Vascular Smooth Muscle Cells in Hypertension

Author(s) -

Wenwen Wu,

Chengping Hu,

X.-P. Chen,

Weifang Zhang,

X.-W. Li,

Xiaofang Xiong,

Y.-J. Li

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2011.116

Subject(s) - vascular smooth muscle , downregulation and upregulation , medicine , endocrinology , microrna , cell growth , angiotensin ii , western blot , microbiology and biotechnology , biology , blood pressure , biochemistry , smooth muscle , gene

It has been reported that microRNA-130a (miR-130a) targets GAX, the growth arrest-specific homeobox, which inhibits proliferation, differentiation, and migration of vascular smooth muscle cells (VSMCs). In the present study, we therefore investigated the effect of miR-130a on proliferation of cultured VSMCs and the potential role of miR-130a in vascular remodeling during hypertension.

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