Open AccessEndothelial-Dependent Flow-Mediated Dilation in African Americans With Masked-Hypertension
Author(s) -
Praveen Veerabhadrappa,
Keith M. Diaz,
Deborah L. Feairheller,
Kathleen M. Sturgeon,
Sheara T. Williamson,
Deborah L. Crabbe,
Abul Kashem,
M.D. Brown
Publication year - 2011
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1038/ajh.2011.103
Subject(s) - medicine , reactive hyperemia , prehypertension , brachial artery , ambulatory blood pressure , masked hypertension , blood pressure , cardiology , endothelium , endothelial dysfunction , endocrinology , blood flow
Office-blood pressure (BP) measurements alone overlook a significant number of individuals with masked-hypertension (office-BP: 120/80-139/89 mm Hg and 24-h ambulatory BP monitoring (ABPM) daytime ≥135/85 mm Hg or night-time ≥120/70 mm Hg). Diminished endothelial function contributes to the pathogenesis of hypertension. To better understand the pathophysiology involved in the increased cardiovascular (CV) disease risk associated with masked-hypertension, we estimated the occurrence, assessed the endothelial function, compared plasma levels of inflammatory markers, white blood cell count (WBC count), tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (hsCRP) and examined the possible relationship between endothelial function and inflammatory markers in apparently healthy prehypertensive (office-BP: 120/80-139/89 mm Hg) African Americans.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom