The Effect of Immune Factors, Tumor Necrosis Factor- , and Agonistic Autoantibodies to the Angiotensin II Type I Receptor on Soluble fms-Like Tyrosine-1 and Soluble Endoglin Production in Response to Hypertension During Pregnancy | Zendy

Marc Parrish | Zendy; Sandra R. Murphy | Zendy; Sarah B. Rutland | Zendy; Kedra Wallace | Zendy; Katrin Wenzel | Zendy; Gerd Wallukat | Zendy; Sharon Keiser | Zendy; Lillian Ray | Zendy; Ralf Dechend | Zendy; James N. Martin | Zendy; Joey P. Granger | Zendy; Babbette LaMarca | Zendy

Open Access

The Effect of Immune Factors, Tumor Necrosis Factor- , and Agonistic Autoantibodies to the Angiotensin II Type I Receptor on Soluble fms-Like Tyrosine-1 and Soluble Endoglin Production in Response to Hypertension During Pregnancy

Author(s) -

Marc Parrish,

Sandra R. Murphy,

Sarah B. Rutland,

Kedra Wallace,

Katrin Wenzel,

Gerd Wallukat,

Sharon Keiser,

Lillian Ray,

Ralf Dechend,

James N. Martin,

Joey P. Granger,

Babbette LaMarca

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.70

Subject(s) - endocrinology , preeclampsia , medicine , angiotensin ii , tumor necrosis factor alpha , angiotensin ii receptor type 1 , autoantibody , cytokine , soluble fms like tyrosine kinase 1 , immune system , receptor , immunology , vascular endothelial growth factor , placental growth factor , antibody , biology , pregnancy , genetics , vegf receptors

Preeclampsia is considered a disease of immunological origin associated with abnormalities in inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), and activated lymphocytes secreting autoantibodies to the angiotensin II receptor (AT1-AA). Recent studies have also demonstrated that an imbalance of angiogenic factors, soluble fms-like tyrosine kinase (sFlt-1), and sEndoglin, exists in preeclampsia; however, the mechanisms that initiate their overproduction are unclear.

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