Heritability and Genetic Linkage of Left Ventricular Mass, Systolic and Diastolic Function in Hypertensive African Americans (From the GENOA Study) | Zendy

Ervin R. Fox | Zendy; Kathy L.E. Klos | Zendy; Alan D. Penman | Zendy; G. J. Blair | Zendy; Benjamin Blossom | Zendy; Donna K. Arnett | Zendy; Richard B. Devereux | Zendy; Tandaw E. Samdarshi | Zendy; Eric Boerwinkle | Zendy; Thomas H. Mosley | Zendy

Open Access

Heritability and Genetic Linkage of Left Ventricular Mass, Systolic and Diastolic Function in Hypertensive African Americans (From the GENOA Study)

Author(s) -

Ervin R. Fox,

Kathy L.E. Klos,

Alan D. Penman,

G. J. Blair,

Benjamin Blossom,

Donna K. Arnett,

Richard B. Devereux,

Tandaw E. Samdarshi,

Eric Boerwinkle,

Thomas H. Mosley

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.67

Subject(s) - medicine , heritability , cardiology , diastole , blood pressure , diastolic function , systole , linkage (software) , genetics , gene , biology

Much of the interindividual variation in left ventricular (LV) structure and function is unexplained by established risk factors and may be due to novel or genetic factors. We used pedigree information from 454 tandem markers across the genome to estimate the heritability and linkage of various echocardiographic measures of LV structure and function in a cohort of African-American hypertensive siblings.

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