Upregulation of AT1R and iNOS in the Rostral Ventrolateral Medulla (RVLM) Is Essential for the Sympathetic Hyperactivity and Hypertension in the 2K-1C Wistar Rat Model | Zendy

Elizabeth Barbosa OliveiraSales | Zendy; Érika E. Nishi | Zendy; M. A. Boim | Zendy; Miriam Sterman Dolnikoff | Zendy; Cássia T. Bergamaschi | Zendy; Ruy R. Campos | Zendy

Open Access

Upregulation of AT1R and iNOS in the Rostral Ventrolateral Medulla (RVLM) Is Essential for the Sympathetic Hyperactivity and Hypertension in the 2K-1C Wistar Rat Model

Author(s) -

Elizabeth Barbosa OliveiraSales,

Érika E. Nishi,

M. A. Boim,

Miriam Sterman Dolnikoff,

Cássia T. Bergamaschi,

Ruy R. Campos

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.64

Subject(s) - rostral ventrolateral medulla , medicine , downregulation and upregulation , essential hypertension , medulla oblongata , cardiology , blood pressure , central nervous system , biology , gene , biochemistry

We hypothesized that upregulation of angiotensin type 1 receptor (AT(1)R) and inducible nitric oxide (NO) synthase (iNOS) within the rostral ventrolateral medulla (RVLM) could contribute to two-kidney, one-clip (2K-1C) hypertension.

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