Inhibition of Angiotensin-Converting Enzyme 2 Exacerbates Cardiac Hypertrophy and Fibrosis in Ren-2 Hypertensive Rats | Zendy

Aaron J. Trask | Zendy; Leanne Groban | Zendy; Brian Westwood | Zendy; Jasmina Varagić | Zendy; Detlev Ganten | Zendy; Patricia E. Gallagher | Zendy; Mark C. Chappell | Zendy; Carlos M. Ferrario | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inhibition of Angiotensin-Converting Enzyme 2 Exacerbates Cardiac Hypertrophy and Fibrosis in Ren-2 Hypertensive Rats

Author(s) -

Aaron J. Trask,

Leanne Groban,

Brian Westwood,

Jasmina Varagić,

Detlev Ganten,

Patricia E. Gallagher,

Mark C. Chappell,

Carlos M. Ferrario

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.51

Subject(s) - medicine , endocrinology , angiotensin ii , angiotensin converting enzyme 2 , muscle hypertrophy , cardiac function curve , cardiac fibrosis , fibrosis , blood pressure , angiotensin converting enzyme , left ventricular hypertrophy , cardiac hypertrophy , renin–angiotensin system , heart failure , disease , covid-19 , infectious disease (medical specialty)

Emerging evidence suggests that cardiac angiotensin-converting enzyme 2 (ACE2) may contribute to the regulation of heart function and hypertension-induced cardiac remodeling. We tested the hypothesis that inhibition of ACE2 in the hearts of (mRen2)27 hypertensive rats may accelerate progression of cardiac hypertrophy and fibrosis by preventing conversion of angiotensin II (Ang II) into the antifibrotic peptide, angiotensin-(1-7) (Ang-(1-7)).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research