TrkB Agonist Antibody Dose-Dependently Raises Blood Pressure in Mice With Diet-Induced Obesity | Zendy

LanPing Xu | Zendy; Yong Zhang | Zendy; Stanley Cohen | Zendy; Keith DiPetrillo | Zendy

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TrkB Agonist Antibody Dose-Dependently Raises Blood Pressure in Mice With Diet-Induced Obesity

Author(s) -

LanPing Xu,

Yong Zhang,

Stanley Cohen,

Keith DiPetrillo

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.49

Subject(s) - tropomyosin receptor kinase b , medicine , rimonabant , endocrinology , agonist , adverse effect , blood pressure , diet induced obese , weight loss , obesity , neurotrophic factors , receptor , insulin resistance , cannabinoid receptor

Brain-derived neurotrophic factor (BDNF) regulates food intake and body weight, but is not useful as a therapeutic because of its short half-life. Chronic activation of its receptor, tyrosine kinase receptor B (TrkB), represents an alternative strategy for lowering body weight. However, because BDNF can raise blood pressure (BP) acutely, it is possible that chronic TrkB activation will produce adverse cardiovascular effects.

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