Histidine-Rich Glycoprotein as an Early Biomarker of Preeclampsia | Zendy

M. Bolin | Zendy; Peter Åkerud | Zendy; Agneta Hansson | Zendy; Helena Åkerud | Zendy

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Histidine-Rich Glycoprotein as an Early Biomarker of Preeclampsia

Author(s) -

M. Bolin,

Peter Åkerud,

Agneta Hansson,

Helena Åkerud

Publication year - 2011

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.264

Subject(s) - preeclampsia , medicine , biomarker , pregnancy , prospective cohort study , obstetrics , gestational hypertension , gestational age , population , cohort study , biochemistry , chemistry , genetics , environmental health , biology

Prediction of preeclampsia is of great interest and the coagulation system as well as the angiogenic pathway is known to be dysfunctional in preeclampsia. Histidine-rich glycoprotein (HRG) is a protein interacting with both these biological systems and the purpose of this prospective, longitudinal cohort study was to analyze whether there is a difference in circulating levels of HRG during pregnancy in women developing preeclampsia compared to normal healthy pregnancies. We furthermore wanted to evaluate whether HRG has the potential of being an early biomarker of preeclampsia.

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