Blockade of AT1 Receptors Protects the Blood-Brain Barrier and Improves Cognition in Dahl Salt-Sensitive Hypertensive Rats | Zendy

Nicolas Pelisch | Zendy; Naohisa Hosomi | Zendy; Masaki Ueno | Zendy; Daisuke Nakano | Zendy; Hirofumi Hitomi | Zendy; Masayuki Mogi | Zendy; Kenji Shimada | Zendy; Hiroyuki Kobori | Zendy; Masatsugu Horiuchi | Zendy; H. Sakamoto | Zendy; Masayasu Matsumoto | Zendy; Masakazu Kohno | Zendy; Akira Nishiyama | Zendy

Open Access

Blockade of AT1 Receptors Protects the Blood-Brain Barrier and Improves Cognition in Dahl Salt-Sensitive Hypertensive Rats

Author(s) -

Nicolas Pelisch,

Naohisa Hosomi,

Masaki Ueno,

Daisuke Nakano,

Hirofumi Hitomi,

Masayuki Mogi,

Kenji Shimada,

Hiroyuki Kobori,

Masatsugu Horiuchi,

H. Sakamoto,

Masayasu Matsumoto,

Masakazu Kohno,

Akira Nishiyama

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.241

Subject(s) - medicine , blockade , angiotensin ii , renin–angiotensin system , blood pressure , blood–brain barrier , angiotensin ii receptor type 1 , pathogenesis , angiotensin receptor , receptor , endocrinology , pharmacology , central nervous system

The present study tested the hypothesis that inappropriate activation of the brain renin-angiotensin system (RAS) contributes to the pathogenesis of blood-brain barrier (BBB) disruption and cognitive impairment during development of salt-dependent hypertension. Effects of an angiotensin II (AngII) type-1 receptor blocker (ARB), at a dose that did not reduce blood pressure, were also examined.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research