Human Dopamine -Hydroxylase Promoter Variant Alters Transcription in Chromaffin Cells, Enzyme Secretion, and Blood Pressure | Zendy

Yuhong Chen | Zendy; Kai Zhang | Zendy; Gen Wen | Zendy; F. Rao | Zendy; Adriana Paula Sanchez | Zendy; Lei Wang | Zendy; Juan L. RodriguezFlores | Zendy; Manjula Mahata | Zendy; Sushil K. Mahata | Zendy; Jill Waalen | Zendy; Michael G. Ziegler | Zendy; Bruce A. Hamilton | Zendy; Daniel T. O’Connor | Zendy

Open Access

Human Dopamine -Hydroxylase Promoter Variant Alters Transcription in Chromaffin Cells, Enzyme Secretion, and Blood Pressure

Author(s) -

Yuhong Chen,

Kai Zhang,

Gen Wen,

F. Rao,

Adriana Paula Sanchez,

Lei Wang,

Juan L. RodriguezFlores,

Manjula Mahata,

Sushil K. Mahata,

Jill Waalen,

Michael G. Ziegler,

Bruce A. Hamilton,

Daniel T. O’Connor

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.186

Subject(s) - medicine , dopamine , secretion , blood pressure , endocrinology , enzyme , tyrosine hydroxylase , transcription factor , gene , genetics , biochemistry , biology

Dopamine β-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine. Here, we characterized a DBH promoter polymorphism (C-2073T; rs1989787; minor allele frequency ~16%) that influences not only gene transcription but also enzyme secretion and blood pressure (BP) in vivo.

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