Vascular Structure and Oxidative Stress in Salt-Loaded Spontaneously Hypertensive Rats: Effects of Losartan and Atenolol | Zendy

Elena M. V. de Cavanagh | Zendy; León Ferder | Zendy; Marcelo Ferder | Zendy; I. Y. Stella | Zendy; J TOBLLI | Zendy; Felipe Inserra | Zendy

Open Access

Vascular Structure and Oxidative Stress in Salt-Loaded Spontaneously Hypertensive Rats: Effects of Losartan and Atenolol

Author(s) -

Elena M. V. de Cavanagh,

León Ferder,

Marcelo Ferder,

I. Y. Stella,

J TOBLLI,

Felipe Inserra

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.167

Subject(s) - atenolol , medicine , oxidative stress , losartan , cardiology , endocrinology , angiotensin ii , pharmacology , blood pressure

Renin-angiotensin system (RAS) modulation by high dietary sodium may contribute to salt-induced hypertension, oxidative stress, and target organ damage. We investigated whether angiotensin II (Ang-II) type 1 (AT1)-receptor blockade (losartan) could protect the aorta and renal arteries from combined hypertension- and high dietary salt-related oxidative stress.

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