Association Study of the Elastin Microfibril Interfacer 1 (EMILIN1) Gene in Essential Hypertension | Zendy

Masanori Shimodaira | Zendy; Takeo Nakayama | Zendy; Naoyuki Sato | Zendy; Tomoka Naganuma | Zendy; Masaru Yamaguchi | Zendy; Noriaki Aoi | Zendy; Masahiko Sato | Zendy; Yasuhiko Izumi | Zendy; Masayoshi Soma | Zendy; Kenji Matsumoto | Zendy

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Association Study of the Elastin Microfibril Interfacer 1 (EMILIN1) Gene in Essential Hypertension

Author(s) -

Masanori Shimodaira,

Takeo Nakayama,

Naoyuki Sato,

Tomoka Naganuma,

Masaru Yamaguchi,

Noriaki Aoi,

Masahiko Sato,

Yasuhiko Izumi,

Masayoshi Soma,

Kenji Matsumoto

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.16

Subject(s) - medicine , elastin , essential hypertension , regulator , blood pressure , homeostasis , endocrinology , gene , pathology , genetics , biology

Elastin microfibril interfacer 1 (EMILIN-1) is a negative regulator of the transforming growth factor-beta (TGF-beta) signaling, which is involved in blood pressure (BP) homeostasis. Emilin1 knockout mice display elevated BP. The aim of the present study was to assess the association between the human EMILIN1 gene and essential hypertension (EH) using a haplotype-based case-control study.

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