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Endothelin-1 (ET-1) is a vasoactive peptide with vasoconstrictor and mitogenic properties. We investigated whether plasma levels of C-terminal pro-ET-1 (CT-proET-1), a newly described stable fragment of the ET-1 precursor, are associated with target-organ damage in hypertension.

Plasma C-Terminal Pro-Endothelin-1 Is Associated With Target-Organ Damage in African Americans With Hypertension