Downregulation of Manganese Superoxide Dismutase by Angiotensin II in Cardiac Fibroblasts of Rats: Association With Oxidative Stress in Myocardium | Zendy

Paul Lijnen | Zendy; Jos van Pelt | Zendy; Robert Fagard | Zendy

Open Access

Downregulation of Manganese Superoxide Dismutase by Angiotensin II in Cardiac Fibroblasts of Rats: Association With Oxidative Stress in Myocardium

Author(s) -

Paul Lijnen,

Jos van Pelt,

Robert Fagard

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.128

Subject(s) - superoxide dismutase , protein kinase b , angiotensin ii , oxidative stress , glutathione peroxidase , catalase , endocrinology , superoxide , phosphorylation , microbiology and biotechnology , medicine , dismutase , biology , chemistry , biochemistry , enzyme , blood pressure

The aim of this study was to determine whether angiotensin II (ANG II) affects the protein and mRNA expressions of the mitochondrial antioxidant manganese superoxide dismutase (Mn-SOD) in cardiac fibroblasts of rats through inducing the phosphorylation of the proteins Akt and FOXO3a, thereby contributing to the oxidative stress in the myocardium.

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