Meta-Analysis of Dose-Response Characteristics of Hydrochlorothiazide and Chlorthalidone: Effects on Systolic Blood Pressure and Potassium | Zendy

Michael E. Ernst | Zendy; Barry Carter | Zendy; Shawn Zheng | Zendy; Richard H. Grimm | Zendy

Open Access

Meta-Analysis of Dose-Response Characteristics of Hydrochlorothiazide and Chlorthalidone: Effects on Systolic Blood Pressure and Potassium

Author(s) -

Michael E. Ernst,

Barry Carter,

Shawn Zheng,

Richard H. Grimm

Publication year - 2010

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1038/ajh.2010.1

Subject(s) - chlorthalidone , medicine , hydrochlorothiazide , blood pressure , cardiology , isolated systolic hypertension , potassium , systole , diastole , pharmacology , metallurgy , materials science

Evidence supporting the benefit of low-dose thiazide-based regimens to reduce cardiovascular events is primarily derived from studies using chlorthalidone, yet low-dose hydrochlorothiazide (HCTZ) (12.5-25 mg) remains more widely prescribed. We sought to describe their comparative dose-response relationships for changes in systolic blood pressure (SBP) and potassium.

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